What Is the Association Between Vitamin C and Hypercholesterolemia

What Is the Association between Vitamin C and Hypercholesterolemia?

• Vitamin C can quench free radicals and prevent oxidative damage to LDL; oxidized LDL tends to stick to the surface of the arterial wall and leads to atherosclerosis.

• Vitamin C also protects HDL in the blood from free radical– induced oxidative damage.


• Vitamin C. A meta-analysis of 13 randomized controlled trials evaluated the relationship between vitamin C and hypercholesterolemia in 1,890 hypercholesterolemia patients. The experimental group received 500 mg of vitamin C daily for 3–24 weeks. Analysis has shown that supplementation with vitamin C decreased LDL levels by 7.9 mg/dl and increased HDL levels by 1.1 mg/dl in patients with hypercholesterolemia. In addition, supplementation with vitamin C was found to lower triglyceride levels by 20.1 mg/dl in patients with hypercholesterolemia.


• Prevention. For people at risk of hypercholesterolemia, take daily 200 mg vitamin C (10).

• Treatment. For hypercholesterolemia patients, take daily 500 mg vitamin C (10).