What Is the Association Between Selenium and Colorectal Cancer

What Is the Association between Selenium and Colorectal Cancer?

• Selenium-dependent enzymes may induce apoptosis and autophagy in cancerous cells. Autophagy is a normal cellular phenomenon in which a cell undergoes a self-destruction process in order to ensure the survival of neighboring cells. However, cancerous cells often undergo autophagy to elude destruction by the host defense system.

• Selenium-dependent enzymes can degrade hydrogen peroxide and prevent it from damaging DNA, leading to gene mutation and tumorigenesis.

A meta-analysis of seven research papers explored the association between selenium and colorectal cancer. Analysis has shown that higher blood levels of selenium reduced the risk of colorectal cancer by 33%.

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