What Is the Association Between Antioxidant and Chronic Pancreatitis

What Is the Association Between Antioxidant and Chronic Pancreatitis

What Is the Association between Antioxidant and Chronic Pancreatitis?

• Consumption of a diet high in protein or fat can lead to sudden abdominal pain in patients with chronic pancreatitis. Antioxidant supplements consisting of selenium, vitamin A, vitamin C, and vitamin E can alleviate the symptoms of chronic pancreatitis.

• Free radical–induced oxidative damage is a major causative factor for chronic pancreatitis. Alcohol consumption, cigarette smoking, and toxic petrochemicals can generate free radicals and initiate oxidative damage to pancreatic cells. Antioxidants—such as vitamin A, vitamin C, and vitamin E—neutralize free radicals, prevent oxidative damage, and alleviate abdominal pain in patients with chronic pancreatitis.

Meta-analysis

• Antioxidants. A meta-analysis of nine randomized controlled trials investigated the relationship between antioxidants and abdominal pain in 390 chronic pancreatitis patients. Analysis confirmed that supplementation with antioxidants significantly reduced abdominal pain in patients with chronic pancreatitis. Only a combination of antioxidants—which included selenium, vitamin A, vitamin C, and vitamin E—was found to be effective in alleviating abdominal pain in patients with chronic pancreatitis. Supplementing with only selenium, vitamin A, vitamin C, or vitamin E alone, however, was ineffective.

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